1.2M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2025 | 1,500 | 33,077 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 71.64 per share. | 18 Mar 2025 | 1,500 | 0 | - | 71.6 | 107,460 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 18 Mar 2025 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Andrew Galligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2025 | 16,829 | 16,829 | - | - | Stock Option (right to buy) | |
| Kristin Myers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2025 | 16,829 | 16,829 | - | - | Stock Option (right to buy) | |
| Rami Elghandour | Director, SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 668,416 | 817,602 | - | 0 | Common Stock | |
| Rami Elghandour | Director, SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 347,255 | 1,164,857 | - | 0 | Common Stock | |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 61.14 per share. | 26 Feb 2025 | 6,334 | 181,152 | - | 61.1 | 387,248 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 62.69 per share. | 26 Feb 2025 | 10,889 | 149,186 | - | 62.7 | 682,625 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 61.95 per share. | 26 Feb 2025 | 21,077 | 160,075 | - | 61.9 | 1,305,644 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 70,211 | 187,486 | - | 0 | Common Stock | |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 70,211 | 0 | - | - | Restricted Stock Unit | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 63.16 per share. | 25 Feb 2025 | 1,500 | 0 | - | 63.2 | 94,740 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2025 | 1,500 | 34,577 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 25 Feb 2025 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 64.26 per share. | 24 Feb 2025 | 5,577 | 37,694 | - | 64.3 | 358,360 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 63.14 per share. | 24 Feb 2025 | 4,370 | 43,271 | - | 63.1 | 275,918 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2025 | 22,556 | 47,641 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2025 | 22,556 | 0 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 64.88 per share. | 24 Feb 2025 | 208 | 37,486 | - | 64.9 | 13,495 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2025 | 70,211 | 187,486 | - | 0 | Common Stock | |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2025 | 70,211 | 0 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2025 | 22,556 | 47,641 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2025 | 22,556 | 0 | - | - | Restricted Stock Unit | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 64.57 per share. | 04 Feb 2025 | 1,500 | 0 | - | 64.6 | 96,855 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 04 Feb 2025 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2025 | 1,500 | 36,077 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2025 | 1,500 | 37,577 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 67.32 per share. | 14 Jan 2025 | 300 | 0 | - | 67.3 | 20,195 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 14 Jan 2025 | 400 | 300 | - | 66.6 | 26,649 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 64.95 per share. | 14 Jan 2025 | 800 | 700 | - | 64.9 | 51,957 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 14 Jan 2025 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 55,459 | 124,712 | - | 0 | Common Stock | |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 53,097 | 177,809 | - | 0 | Common Stock | |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 79.55 per share. | 02 Jan 2025 | 14,857 | 162,952 | - | 79.5 | 1,181,846 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 77.17 per share. | 02 Jan 2025 | 13,776 | 149,176 | - | 77.2 | 1,063,050 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 55,459 | 110,918 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 53,097 | 53,098 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, SEE REMARKS | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 223,964 | 223,964 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 52,258 | 52,258 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 52,258 | 52,258 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 13,021 | 22,299 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 16,519 | 38,818 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 79.55 per share. | 02 Jan 2025 | 3,301 | 35,517 | - | 79.5 | 262,588 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 77.17 per share. | 02 Jan 2025 | 3,061 | 32,456 | - | 77.2 | 236,208 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 13,021 | 26,042 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 16,519 | 16,520 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 13,021 | 22,299 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 16,519 | 38,818 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 79.55 per share. | 02 Jan 2025 | 3,301 | 35,517 | - | 79.5 | 262,588 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 77.17 per share. | 02 Jan 2025 | 3,061 | 32,456 | - | 77.2 | 236,208 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 13,021 | 26,042 | - | - | Restricted Stock Unit | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 16,519 | 16,520 | - | - | Restricted Stock Unit | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 15,339 | 38,834 | - | 0 | Common Stock | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 79.55 per share. | 02 Jan 2025 | 5,502 | 33,332 | - | 79.5 | 437,674 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 77.17 per share. | 02 Jan 2025 | 5,102 | 28,230 | - | 77.2 | 393,705 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 20,495 | 40,992 | - | - | Restricted Stock Unit | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 15,339 | 15,340 | - | - | Restricted Stock Unit | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 82,120 | 82,120 | - | - | Restricted Stock Unit | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 20,495 | 23,495 | - | 0 | Common Stock | |
| Patel Kavita K. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Dec 2024 | 1,500 | 39,077 | - | - | Stock Option (right to buy) | |
| K. Patel Kavita | Director | Sale of securities on an exchange or to another person at price $ 77.61 per share. | 24 Dec 2024 | 100 | 0 | - | 77.6 | 7,761 | Common Stock |
| Patel Kavita K. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 24 Dec 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Patel K. Kavita | Director | Sale of securities on an exchange or to another person at price $ 76.92 per share. | 24 Dec 2024 | 1,400 | 100 | - | 76.9 | 107,690 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 96.05 per share. | 03 Dec 2024 | 300 | 0 | - | 96.0 | 28,814 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 03 Dec 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2024 | 1,500 | 40,577 | - | - | Stock Option (right to buy) | |
| Kavita Patel K. | Director | Sale of securities on an exchange or to another person at price $ 93.76 per share. | 03 Dec 2024 | 300 | 300 | - | 93.8 | 28,127 | Common Stock |
| Patel K. Kavita | Director | Sale of securities on an exchange or to another person at price $ 91.90 per share. | 03 Dec 2024 | 200 | 600 | - | 91.9 | 18,381 | Common Stock |
| Patel Kavita K. | Director | Sale of securities on an exchange or to another person at price $ 89.84 per share. | 03 Dec 2024 | 400 | 800 | - | 89.8 | 35,937 | Common Stock |
| Patel Kavita K. | Director | Sale of securities on an exchange or to another person at price $ 88.53 per share. | 03 Dec 2024 | 300 | 1,200 | - | 88.5 | 26,559 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 87.89 per share. | 15 Nov 2024 | 1,061 | 700 | - | 87.9 | 93,255 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2024 | 3,000 | 78,315 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.66 per share. | 15 Nov 2024 | 3,000 | 3,000 | - | 8.7 | 25,980 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 95.00 per share. | 15 Nov 2024 | 100 | 0 | - | 95 | 9,500 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 91.67 per share. | 15 Nov 2024 | 100 | 100 | - | 91.7 | 9,167 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 89.17 per share. | 15 Nov 2024 | 500 | 200 | - | 89.2 | 44,586 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2024 | 1,500 | 42,077 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 106.33 per share. | 12 Nov 2024 | 1,500 | 0 | - | 106.3 | 159,495 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 12 Nov 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 100.26 per share. | 08 Nov 2024 | 9,700 | 4,415 | - | 100.3 | 972,554 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.66 per share. | 08 Nov 2024 | 7,200 | 14,115 | - | 8.7 | 62,352 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2024 | 7,200 | 81,315 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 102.33 per share. | 08 Nov 2024 | 801 | 1,761 | - | 102.3 | 81,970 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 101.27 per share. | 08 Nov 2024 | 1,853 | 2,562 | - | 101.3 | 187,646 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 106.91 per share. | 07 Nov 2024 | 3,005 | 0 | - | 106.9 | 321,259 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 105.68 per share. | 07 Nov 2024 | 12,233 | 3,005 | - | 105.7 | 1,292,747 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 07 Nov 2024 | 15,238 | 15,238 | - | 15 | 228,570 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 105.46 per share. | 07 Nov 2024 | 25,787 | 0 | - | 105.5 | 2,719,515 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 100.57 per share. | 07 Nov 2024 | 2,076 | 25,787 | - | 100.6 | 208,789 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 99.60 per share. | 07 Nov 2024 | 5,900 | 27,863 | - | 99.6 | 587,637 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 07 Nov 2024 | 25,787 | 33,763 | - | 15 | 386,805 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 07 Nov 2024 | 7,976 | 7,976 | - | 6.7 | 53,120 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 07 Nov 2024 | 8,478 | 8,478 | - | 6.7 | 56,463 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 99.30 per share. | 07 Nov 2024 | 8,478 | 0 | - | 99.3 | 841,861 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2024 | 15,238 | 20,513 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2024 | 25,787 | 35,751 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2024 | 7,976 | 43,577 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Nov 2024 | 8,478 | 51,553 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 89.69 per share. | 22 Oct 2024 | 1,500 | 0 | - | 89.7 | 134,535 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Oct 2024 | 1,500 | 60,031 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 22 Oct 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 01 Oct 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 1,500 | 61,531 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 82.24 per share. | 01 Oct 2024 | 1,500 | 0 | - | 82.2 | 123,360 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 77.51 per share. | 17 Sep 2024 | 6,274 | 15,641 | - | 77.5 | 486,291 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2024 | 15,000 | 88,515 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 77.88 per share. | 17 Sep 2024 | 8,726 | 6,915 | - | 77.9 | 679,589 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.66 per share. | 17 Sep 2024 | 15,000 | 21,915 | - | 8.7 | 129,900 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 10 Sep 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 1,500 | 63,031 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 74.41 per share. | 10 Sep 2024 | 1,500 | 0 | - | 74.4 | 111,615 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Sep 2024 | 3,421 | 132,416 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 70.02 per share. | 05 Sep 2024 | 3,421 | 9,278 | - | 70.0 | 239,526 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 05 Sep 2024 | 3,421 | 12,699 | - | 15 | 51,315 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 03 Sep 2024 | 22,000 | 31,278 | - | 15 | 330,000 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,451 | 43,604 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 22,000 | 135,837 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 70.07 per share. | 03 Sep 2024 | 2,900 | 9,278 | - | 70.1 | 203,202 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 69.06 per share. | 03 Sep 2024 | 1,200 | 12,178 | - | 69.1 | 82,872 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 68.01 per share. | 03 Sep 2024 | 1,958 | 13,378 | - | 68.0 | 133,168 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 67.24 per share. | 03 Sep 2024 | 6,617 | 15,336 | - | 67.2 | 444,899 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 66.05 per share. | 03 Sep 2024 | 14,776 | 21,953 | - | 66.0 | 975,912 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 03 Sep 2024 | 5,451 | 36,729 | - | 6.3 | 34,232 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 70.61 per share. | 26 Aug 2024 | 6,432 | 24,530 | - | 70.6 | 454,165 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 21,684 | 157,837 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 71.34 per share. | 26 Aug 2024 | 15,252 | 9,278 | - | 71.3 | 1,088,108 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 26 Aug 2024 | 21,684 | 30,962 | - | 15 | 325,260 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 20 Aug 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 65.88 per share. | 20 Aug 2024 | 1,500 | 0 | - | 65.9 | 98,820 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 1,500 | 64,531 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 65.05 per share. | 16 Aug 2024 | 5,450 | 9,278 | - | 65.1 | 354,526 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 16 Aug 2024 | 5,450 | 14,728 | - | 6.3 | 34,226 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2024 | 5,450 | 49,055 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 01 Aug 2024 | 9,316 | 18,594 | - | 6.3 | 58,504 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 10,684 | 179,521 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 9,316 | 54,505 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 61.13 per share. | 01 Aug 2024 | 732 | 9,278 | - | 61.1 | 44,746 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.39 per share. | 01 Aug 2024 | 19,268 | 10,010 | - | 60.4 | 1,163,689 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 01 Aug 2024 | 10,684 | 29,278 | - | 15 | 160,260 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 61.81 per share. | 30 Jul 2024 | 1,300 | 200 | - | 61.8 | 80,359 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 1,500 | 66,031 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 62.95 per share. | 30 Jul 2024 | 200 | 0 | - | 63.0 | 12,590 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 30 Jul 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 65.30 per share. | 16 Jul 2024 | 10,901 | 9,278 | - | 65.3 | 711,854 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 10,901 | 63,821 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 16 Jul 2024 | 10,901 | 20,179 | - | 6.3 | 68,458 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 11 Jul 2024 | 3,671 | 12,949 | - | 6.3 | 23,054 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2024 | 1,780 | 74,722 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2024 | 3,671 | 76,502 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.21 per share. | 11 Jul 2024 | 1,780 | 9,278 | - | 60.2 | 107,175 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 11 Jul 2024 | 1,780 | 11,058 | - | 6.3 | 11,178 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.01 per share. | 11 Jul 2024 | 3,671 | 9,278 | - | 60.0 | 220,302 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 57.15 per share. | 09 Jul 2024 | 648 | 0 | - | 57.2 | 37,036 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 56.23 per share. | 09 Jul 2024 | 852 | 648 | - | 56.2 | 47,911 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 09 Jul 2024 | 1,500 | 1,500 | - | 6.7 | 9,990 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2024 | 1,500 | 67,531 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 01 Jul 2024 | 12,964 | 29,278 | - | 15 | 194,460 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 55.26 per share. | 01 Jul 2024 | 17,217 | 12,061 | - | 55.3 | 951,372 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 56.20 per share. | 01 Jul 2024 | 2,783 | 9,278 | - | 56.2 | 156,391 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 7,036 | 80,173 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 12,964 | 190,205 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 01 Jul 2024 | 7,036 | 16,314 | - | 6.3 | 44,186 | Common Stock |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 54.02 per share. | 27 Jun 2024 | 4,971 | 5,029 | - | 54.0 | 268,548 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.66 per share. | 27 Jun 2024 | 10,000 | 10,000 | - | 6.7 | 66,600 | Common Stock |
| Kavita K. Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jun 2024 | 10,000 | 69,031 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Sale of securities on an exchange or to another person at price $ 54.51 per share. | 27 Jun 2024 | 5,029 | 0 | - | 54.5 | 274,109 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 53.68 per share. | 26 Jun 2024 | 12,326 | 7,466 | - | 53.7 | 661,628 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 54.25 per share. | 26 Jun 2024 | 551 | 6,915 | - | 54.2 | 29,891 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 12 Jun 2024 | 7,964 | 17,242 | - | 6.3 | 50,014 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 12,036 | 203,169 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 7,964 | 87,209 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 56.04 per share. | 12 Jun 2024 | 82 | 9,278 | - | 56.0 | 4,595 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 55.13 per share. | 12 Jun 2024 | 19,918 | 9,360 | - | 55.1 | 1,098,073 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 12 Jun 2024 | 12,036 | 29,278 | - | 15 | 180,540 | Common Stock |
| David Charles Lubner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 8,011 | 8,011 | - | - | Stock Option (right to buy) | |
| Jill Carroll | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 8,011 | 8,011 | - | - | Stock Option (right to buy) | |
| Olivia C. Ware | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 8,011 | 8,011 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 8,011 | 8,011 | - | - | Stock Option (right to buy) | |
| Derek Yoon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 8,011 | 8,011 | - | - | Stock Option (right to buy) | |
| Ali Behbahani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 8,011 | 8,011 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2024 | 22,428 | 22,429 | - | - | Restricted Stock Units | |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 50.71 per share. | 23 May 2024 | 12,121 | 19,792 | - | 50.7 | 614,656 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2024 | 22,428 | 31,913 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 01 May 2024 | 18,168 | 27,106 | - | 6.3 | 114,095 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 52.63 per share. | 01 May 2024 | 500 | 9,038 | - | 52.6 | 26,314 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 53.55 per share. | 01 May 2024 | 100 | 8,938 | - | 53.6 | 5,355 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 10,000 | 95,173 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 8,168 | 10,901 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 51.48 per share. | 01 May 2024 | 10,481 | 9,538 | - | 51.5 | 539,542 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 50.99 per share. | 01 May 2024 | 7,087 | 20,019 | - | 51.0 | 361,346 | Common Stock |
| Olivia C. Ware | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2024 | 9,402 | 36,806 | - | - | Stock Option (right to buy) | |
| Olivia C. Ware | Director | Sale of securities on an exchange or to another person at price $ 56.03 per share. | 16 Apr 2024 | 2,612 | 0 | - | 56.0 | 146,353 | Common Stock |
| Olivia C. Ware | Director | Sale of securities on an exchange or to another person at price $ 55.36 per share. | 16 Apr 2024 | 6,790 | 2,612 | - | 55.4 | 375,907 | Common Stock |
| Olivia C. Ware | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.61 per share. | 16 Apr 2024 | 9,402 | 9,402 | - | 7.6 | 71,549 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 66.67 per share. | 01 Apr 2024 | 14,919 | 77,420 | - | 66.7 | 994,680 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 67.58 per share. | 01 Apr 2024 | 5,456 | 71,964 | - | 67.6 | 368,731 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 68.42 per share. | 01 Apr 2024 | 2,711 | 69,253 | - | 68.4 | 185,476 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2024 | 5,450 | 105,173 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2024 | 10,000 | 19,069 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2024 | 10,000 | 110,623 | - | - | Stock Option (right to buy) | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 70.19 per share. | 22 Mar 2024 | 861 | 8,938 | - | 70.2 | 60,431 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 69.36 per share. | 22 Mar 2024 | 2,034 | 9,799 | - | 69.4 | 141,079 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 68.55 per share. | 22 Mar 2024 | 2,555 | 11,833 | - | 68.5 | 175,138 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 22 Mar 2024 | 5,450 | 14,388 | - | 6.3 | 34,226 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 72.25 per share. | 22 Mar 2024 | 1,000 | 8,938 | - | 72.2 | 72,247 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 71.36 per share. | 22 Mar 2024 | 4,333 | 9,938 | - | 71.4 | 309,211 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 70.13 per share. | 22 Mar 2024 | 25,975 | 14,271 | - | 70.1 | 1,821,697 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 69.59 per share. | 22 Mar 2024 | 10,057 | 40,246 | - | 69.6 | 699,911 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 22 Mar 2024 | 20,000 | 50,303 | - | 6.3 | 125,600 | Common Stock |
| Jill Carroll | Director | Sale of securities on an exchange or to another person at price $ 70.55 per share. | 21 Mar 2024 | 504,263 | 1,479,148 | - | 70.6 | 35,575,755 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 69.73 per share. | 18 Mar 2024 | 3,043 | 9,485 | - | 69.7 | 212,192 | Common Stock |
| Michelle Gilson | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 69.03 per share. | 18 Mar 2024 | 3,782 | 12,528 | - | 69.0 | 261,063 | Common Stock |
| Olivia C. Ware | Director | Sale of securities on an exchange or to another person at price $ 70.99 per share. | 15 Mar 2024 | 3,337 | 0 | - | 71.0 | 236,881 | Common Stock |
| Olivia C. Ware | Director | Sale of securities on an exchange or to another person at price $ 70.36 per share. | 15 Mar 2024 | 3,763 | 3,337 | - | 70.4 | 264,768 | Common Stock |
| Olivia C. Ware | Director | Sale of securities on an exchange or to another person at price $ 69.44 per share. | 15 Mar 2024 | 1,900 | 7,100 | - | 69.4 | 131,932 | Common Stock |
| Olivia C. Ware | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 9,000 | 46,208 | - | - | Stock Option (right to buy) | |
| Olivia C. Ware | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.61 per share. | 15 Mar 2024 | 9,000 | 9,000 | - | 7.6 | 68,490 | Common Stock |
| Rami Elghandour | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 64.46 per share. | 08 Feb 2024 | 11,169 | 92,339 | - | 64.5 | 719,948 | Common Stock |
| Heery Christopher | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 63.40 per share. | 08 Feb 2024 | 3,688 | 33,270 | - | 63.4 | 233,811 | Common Stock |
| Elghandour Rami | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 63.40 per share. | 08 Feb 2024 | 13,886 | 103,508 | - | 63.4 | 880,340 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 62.29 per share. | 08 Feb 2024 | 3,456 | 36,958 | - | 62.3 | 215,290 | Common Stock |
| Christopher Heery | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 64.46 per share. | 08 Feb 2024 | 2,967 | 30,303 | - | 64.5 | 191,251 | Common Stock |
| Elghandour Rami | Director, SEE REMARKS | Sale of securities on an exchange or to another person at price $ 62.29 per share. | 08 Feb 2024 | 13,010 | 117,394 | - | 62.3 | 810,451 | Common Stock |
| Elghandour Rami | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2024 | 70,211 | 130,404 | - | 0 | Common Stock | |
| Christopher Heery | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2024 | 22,555 | 22,556 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, SEE REMARKS | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2024 | 70,211 | 70,211 | - | - | Restricted Stock Unit | |
| Heery Christopher | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2024 | 22,555 | 40,414 | - | 0 | Common Stock | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.27 per share. | 04 Jan 2024 | 7,598 | 17,859 | - | 55.3 | 419,926 | Common Stock |
| Michelle Gilson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 55.27 per share. | 04 Jan 2024 | 8,514 | 16,310 | - | 55.3 | 470,551 | Common Stock |
| Elghandour Rami | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 55.27 per share. | 04 Jan 2024 | 29,073 | 60,193 | - | 55.3 | 1,606,804 | Common Stock |
| Heery Christopher | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 60,096 | 60,096 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 39,063 | 39,063 | - | - | Restricted Stock Unit | |
| Gilson Michelle | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 15,339 | 30,679 | - | - | Restricted Stock Unit | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 94,596 | 94,596 | - | - | Stock Option (right to buy) | |
| Rami Elghandour | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 53,097 | 106,195 | - | - | Restricted Stock Unit | |
| Elghandour Rami | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 255,965 | 255,965 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 16,519 | 33,039 | - | - | Restricted Stock Unit | |
| Gilson Michelle | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 15,339 | 24,824 | - | 0 | Common Stock | |
| Heery Christopher | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 16,519 | 25,457 | - | 0 | Common Stock | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 61,487 | 61,487 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 166,377 | 166,377 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 53,097 | 89,266 | - | 0 | Common Stock | |
| Heery Christopher | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 51.86 per share. | 18 Dec 2023 | 845 | 7,795 | - | 51.9 | 43,823 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.06 per share. | 18 Dec 2023 | 106,912 | 20,883 | - | 50.1 | 5,351,758 | Common Stock |
| Heery Christopher | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2023 | 120,000 | 120,623 | - | - | Stock Option (right to buy) | |
| Heery Christopher | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 18 Dec 2023 | 120,000 | 127,795 | - | 6.3 | 753,600 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 51.03 per share. | 18 Dec 2023 | 12,243 | 8,640 | - | 51.0 | 624,700 | Common Stock |
| Carroll Jill | Director | Sale of securities on an exchange or to another person at price $ 49.13 per share. | 14 Dec 2023 | 504,263 | 1,983,411 | - | 49.1 | 24,774,441 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2023 | 3,000 | 215,205 | - | - | Common Stock | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.38 per share. | 04 Aug 2023 | 3,000 | 7,795 | - | 35.4 | 106,133 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 04 Aug 2023 | 3,000 | 10,795 | - | 15 | 45,000 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 03 Jul 2023 | 3,000 | 10,795 | - | 15 | 45,000 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2023 | 3,000 | 218,205 | - | - | Common Stock | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.75 per share. | 03 Jul 2023 | 3,000 | 7,795 | - | 31.7 | 95,246 | Common Stock |
| David Charles Lubner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 11,459 | 11,459 | - | - | Stock Option (right to buy) | |
| Jill Carroll | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 11,459 | 11,459 | - | - | Stock Option (right to buy) | |
| Ali Behbahani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 11,459 | 11,459 | - | - | Stock Option (right to buy) | |
| Olivia C. Ware | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 11,459 | 11,459 | - | - | Stock Option (right to buy) | |
| Kavita K. Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 11,459 | 11,459 | - | - | Stock Option (right to buy) | |
| Derek Yoon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 11,459 | 11,459 | - | - | Stock Option (right to buy) | |
| Ali Behbahani | Director | Other type of transaction at price $ 0.00 per share. | 01 Jun 2023 | 28 | 85 | - | 0 | Common Stock | |
| Ali Behbahani | Director | Other type of transaction at price $ 0.00 per share. | 01 Jun 2023 | 113 | 339 | - | 0 | Common Stock | |
| Jill Carroll | Director | Sale of securities on an exchange or to another person at price $ 44.35 per share. | 31 May 2023 | 25,556 | 2,487,674 | - | 44.3 | 1,133,317 | Common Stock |
| Jill Carroll | Director | Sale of securities on an exchange or to another person at price $ 41.50 per share. | 31 May 2023 | 315,164 | 2,513,230 | - | 41.5 | 13,079,306 | Common Stock |
| Rami Elghandour | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 44.27 per share. | 31 May 2023 | 2,600 | 36,169 | - | 44.3 | 115,099 | Common Stock |
| Michelle Gilson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 42.47 per share. | 23 May 2023 | 8,554 | 15,635 | - | 42.5 | 363,288 | Common Stock |
| Michelle Gilson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2023 | 22,428 | 44,857 | - | - | Restricted Stock Units | |
| Michelle Gilson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 42.77 per share. | 23 May 2023 | 6,000 | 9,485 | - | 42.8 | 256,616 | Common Stock |
| Michelle Gilson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 41.64 per share. | 23 May 2023 | 150 | 15,485 | - | 41.6 | 6,246 | Common Stock |
| Michelle Gilson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2023 | 22,428 | 24,189 | - | 0 | Common Stock | |
| Jill Carroll | Director | Sale of securities on an exchange or to another person at price $ 46.15 per share. | 11 May 2023 | 6,485 | 2,828,394 | - | 46.2 | 299,283 | Common Stock |
| Jill Carroll | Director | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 11 May 2023 | 631,932 | 2,834,879 | - | 45 | 28,436,940 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 09 May 2023 | 500 | 9,992 | - | 45 | 22,500 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.18 per share. | 09 May 2023 | 2,197 | 7,795 | - | 45.2 | 99,266 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 05 May 2023 | 1,200 | 10,492 | - | 45.0 | 54,002 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 42.72 per share. | 03 May 2023 | 400 | 14,292 | - | 42.7 | 17,086 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2023 | 3,000 | 221,205 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 43.56 per share. | 03 May 2023 | 2,600 | 11,692 | - | 43.6 | 113,243 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 03 May 2023 | 3,000 | 14,692 | - | 15 | 45,000 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 24 Apr 2023 | 10,000 | 31,692 | - | 15 | 150,000 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 24 Apr 2023 | 10,000 | 21,692 | - | 6.3 | 62,800 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 24 Apr 2023 | 20,000 | 11,692 | - | 40.0 | 800,068 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2023 | 10,000 | 240,623 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2023 | 10,000 | 224,205 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 18 Apr 2023 | 3,000 | 18,589 | - | 6.3 | 18,840 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 9,745 | 234,205 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 2,600 | 250,623 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 2,400 | 243,950 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 3,000 | 253,223 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 18 Apr 2023 | 15,642 | 11,692 | - | 35.0 | 547,661 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 18 Apr 2023 | 9,745 | 27,334 | - | 15 | 146,175 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 18 Apr 2023 | 2,600 | 17,589 | - | 6.3 | 16,328 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 18 Apr 2023 | 6,000 | 14,989 | - | 35 | 210,000 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 18 Apr 2023 | 2,400 | 20,989 | - | 15 | 36,000 | Common Stock |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.63 per share. | 03 Apr 2023 | 2,598 | 15,991 | - | 30.6 | 79,589 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2023 | 3,000 | 246,350 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.17 per share. | 03 Apr 2023 | 402 | 15,589 | - | 31.2 | 12,531 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 03 Apr 2023 | 3,000 | 18,589 | - | 15 | 45,000 | Common Stock |
| Rami Elghandour | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 30.77 per share. | 07 Feb 2023 | 31,442 | 38,769 | - | 30.8 | 967,423 | Common Stock |
| Rami Elghandour | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2023 | 70,211 | 140,422 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2023 | 70,211 | 70,211 | - | 0 | Common Stock | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2023 | 22,555 | 22,555 | - | 0 | Common Stock | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2023 | 22,555 | 45,111 | - | - | Restricted Stock Unit | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.77 per share. | 07 Feb 2023 | 6,966 | 15,589 | - | 30.8 | 214,333 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 03 Feb 2023 | 855 | 1,255 | - | 15 | 12,825 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 855 | 249,350 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 400 | 256,223 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.11 per share. | 03 Feb 2023 | 1,255 | 0 | - | 35.1 | 44,068 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 03 Feb 2023 | 400 | 400 | - | 6.3 | 2,512 | Common Stock |
| Rami Elghandour | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 159,292 | 159,292 | - | - | Restricted Stock Unit | |
| Rami Elghandour | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 245,065 | 245,065 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 03 Jan 2023 | 2,500 | 2,500 | - | 15 | 37,500 | Common Stock |
| Christopher Heery | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 76,242 | 76,242 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.11 per share. | 03 Jan 2023 | 2,500 | 0 | - | 31.1 | 77,775 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 2,500 | 250,205 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 49,558 | 49,558 | - | - | Restricted Stock Unit | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 70,796 | 70,796 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 46,018 | 46,018 | - | - | Restricted Stock Unit | |
| Ali Behbahani | Director | Other type of transaction at price $ 0.00 per share. | 20 Dec 2022 | 226 | 226 | - | 0 | Common Stock | |
| Ali Behbahani | Director | Other type of transaction at price $ 0.00 per share. | 20 Dec 2022 | 57 | 57 | - | 0 | Common Stock | |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 5,000 | 256,623 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.03 per share. | 13 Dec 2022 | 12,500 | 0 | - | 30.0 | 375,320 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.00 per share. | 13 Dec 2022 | 7,500 | 12,500 | - | 15 | 112,500 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.28 per share. | 13 Dec 2022 | 5,000 | 5,000 | - | 6.3 | 31,400 | Common Stock |
| Christopher Heery | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 7,500 | 252,705 | - | - | Stock Option (right to buy) | |
| Rami Elghandour | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Sep 2022 | 120,000 | 120,000 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Sep 2022 | 40,000 | 40,000 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Sep 2022 | 32,500 | 32,500 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2022 | 103,515 | 103,515 | - | - | Stock Option (right to buy) | |
| Michelle Gilson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2022 | 67,285 | 67,285 | - | - | Restricted Stock Units | |
| Olivia C. Ware | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2022 | 55,208 | 55,208 | - | - | Stock Option (right to buy) | |
| Lewis T. Williams | Director | 08 Feb 2022 | 1,163,886 | 0 | - | - | Series B-1 Preferred Stock | ||
| Lewis T. Williams | Director | 08 Feb 2022 | 931,228 | 0 | - | - | Series B-2 Preferred Stock | ||
| Lewis T. Williams | Director | 08 Feb 2022 | 2,095,114 | 2,095,114 | - | 0 | Common Stock | ||
| David Charles Lubner | Director | 08 Feb 2022 | 21,659 | 0 | - | - | Series C Preferred Stock | ||
| David Charles Lubner | Director | 08 Feb 2022 | 21,659 | 21,659 | - | 0 | Common Stock | ||
| Jill Carroll | Director | 08 Feb 2022 | 1,550,309 | 0 | - | - | Series A Preferred Stock | ||
| Jill Carroll | Director | 08 Feb 2022 | 3,400,144 | 3,400,144 | - | 0 | Common Stock | ||
| Jill Carroll | Director | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 08 Feb 2022 | 66,667 | 3,466,811 | - | 15 | 1,000,005 | Common Stock |
| Jill Carroll | Director | 08 Feb 2022 | 433,196 | 433,196 | - | 0 | Common Stock | ||
| Jill Carroll | Director | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 08 Feb 2022 | 1,600,000 | 2,033,196 | - | 15 | 24,000,000 | Common Stock |
| Jill Carroll | Director | 08 Feb 2022 | 666,651 | 0 | - | - | Series B-1 Preferred Stock | ||
| Jill Carroll | Director | 08 Feb 2022 | 533,389 | 0 | - | - | Series B-2 Preferred Stock | ||
| Jill Carroll | Director | 08 Feb 2022 | 649,795 | 0 | - | - | Series C Preferred Stock | ||
| Jill Carroll | Director | 08 Feb 2022 | 433,196 | 0 | - | - | Series C Preferred Stock | ||
| David Charles Lubner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 61,538 | 61,538 | - | - | Stock Option (right to buy) | |
| Rami Elghandour | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 810,102 | 810,102 | - | - | Stock Option (right to buy) | |
| Rami Elghandour | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 210,633 | 210,633 | - | - | Restricted Stock Unit | |
| Kavita K. Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 61,538 | 61,538 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 260,205 | 260,205 | - | - | Stock Option (right to buy) | |
| Christopher Heery | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 67,666 | 67,666 | - | - | Restricted Stock Unit |